The GOP are headed back to Washington after the holiday break to begin the 114th Congress on Tuesday holding 246 seats in the House and 54 seats in the Senate, and they will focus on the economy and cutting the federal budget.

The 246 seats Republicans hold in the House represents their largest lead since the Great Depression, according to a Fox News report.

As Congress gets back to work, Republicans will now be responsible for legislation, and GOP leadership will be eager to focus on their priorities, both introducing new legislation and battling with Obama on a number of issues.

Sen. Mitch McConnell (R-Ky.), the newly minted Senate majority leader, said the Senate’s first bill would require construction of the Keystone XL oil pipeline, something that Republicans tout as a job creator but President Obama and Democrats say is environment destroyer with a relatively small benefit in jobs, according to an Associated Press report.

Also, the House will attempt to undermine the Affordable Care Act, or Obamacare, with some legislation that will permit small companies to sidestep some of the requirements of the bill, specifically by hiring veterans. It will also attempt to push through Keystone pipeline legislation.

Obama’s executive actions on immigration will also be a target, and Republicans will also seek to reduce environmental and business regulations that they contend are inhibiting job growth. They will try to cut back on spending, reduce Medicare and other benefits, and help increase the speed of approval of trade treaties. Mostly, they are focused on job creation, said House Majority Leader Kevin McCarthy (R-Calif.).

However, Democrats argue that Republican measures are more focused on helping the rich while minimizing Obama’s accomplishments, especially the Affordable Care Act.

Democrats know there is little they can do to keep Republicans from setting the agenda after the Republicans captured control of the Senate and expanded their lead in the House in November’s midterm elections. They still have a Democratic president who can threaten to veto legislation in his last two years in office until the next election year, 2016, when Democrats hope to install another party candidate in the White House and possibly retake the Senate and chip away at the GOP’s lead in the House.

The Republicans lead in the House was just 13 seats before the election, but now stands at a commanding 246-188 with one vacancy.