Helena Bonham Carter has starred in five of Tim Burton’s films since they met on the set of Planet of the Apes in 2001, but troubles in the couple’s romantic relationship may put an end to their extremely successful working relationship. Representatives for the duo confirmed to E! News on Tuesday that Bonham Carter and Burton have separated after being together for 13 years.

Rumors began to spread during filming of Planet of the Apes that Bonham Carter and the film’s director, Burton, were secretly dating. Bonham Carter’s representative confirmed the relationship to the New York Daily News later that year, but said that they didn’t begin dating during filming since being costumed in latex “from head to toe” would have made it impossible for Bonham Carter to get intimate.

“She has been seeing him for the last two and a half weeks. It is a baby relationship,” said the rep. “They’re taking baby steps. It didn’t start during ‘Planet of the Apes.”

Burton then cast his girlfriend in 2003’s Big Fish, 2005’s Charlie and the Chocolate Factory, 2007’s Sweeney Todd: The Demon Barber of Fleet Street, 2010’s Alice in Wonderland and 2012’s Dark Shadows. While their professional relationship was frequently praised by the media, rumors began to spread in 2010 that the couple were experiencing some intimacy issues and were thus sleeping in separate beds.

Bonham Carter quickly addressed the subject with the U.K.’s Radio Times, stating “We just have two houses knocked together because mine was too small. We see as much of each other as any couple, but our relationship is enhanced by knowing we have our personal space to retreat to.” However, Bonham Carter was again forced to defend their relationship in 2013, when photos purportedly of Burton kissing another woman were published.

“This is an absolute nonsense story, the pictures were taken whilst they were out and the large group includes family, friends and work colleagues,” her representative told Us Weekly.

Representatives for the couple have not yet explained whether their breakup was due to the rumored intimacy issues or Burton’s potential infidelity, but told E! News Monday the couple separated “amicably” earlier this year, and that they “have continued to be friends and co-parent” their son Billy and daughter Nell.

“We would ask that you respect their privacy and that of their children during this time,” concluded the reps.